| 摘要 |
The application is directed to TGF analogs/derepressors that bind to and neutralize cystine knot-containing BMP antagonists-such as the CAN subfamily of Cystine-knot proteins including sclerostin. The subject TGF derepressors can be prepared as substantially pyrogen-free pharmaceutical compositions for administration to mammals, in treating diseases such as bone diseases including osteoporosis, and any conditions with lesser-than-desired amount of BMP activity.
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