发明名称 |
METHOD OF PRODUCING A MULTICHIMERIC MOUSE AND APPLICATIONS TO STUDY THE IMMUNOPATHOGENESIS OF HUMAN TISSUE-SPECIFIC PATHOLOGIES |
摘要 |
The invention relates to a method of producing a multichimeric mouse comprising a functional xenogenic (human) immune system restricted to the MHC class I and/or class II molecules (HLA molecules) of the xenogenic species solely, and a functional tissue. The invention relates also to the use of the multichimeric mouse obtainable by said method, to study the immunopathogenesis of tissue-specific diseases (infectious, tumoral or auto-immune pathologies) and to their applications to design and test vaccines or immunotherapeutic agents against these pathologies. |
申请公布号 |
WO2008010099(A3) |
申请公布日期 |
2008.05.22 |
申请号 |
WO2007IB03055 |
申请日期 |
2007.07.13 |
申请人 |
INSTITUT PASTEUR;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE RENE DESCARTES (PARIS V);GARCIA, SYLVIE;TARTOUR, ERIC |
发明人 |
GARCIA, SYLVIE;TARTOUR, ERIC |
分类号 |
C12N15/85;A01K67/027;G01N33/50 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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