<p>Stably cross-linked a polypeptides related to human MAML are described. These cross-linked polypeptides contain at least two modified amino acids that together form an internal cross-link or tether that can help to stabilize the alpha-helical secondary structure that is thought to be important for binding of MAML peptides to the Notch transcription complex, a complex that includes ICN and CSL.</p>
申请公布号
WO2008061192(A2)
申请公布日期
2008.05.22
申请号
WO2007US84838
申请日期
2007.11.15
申请人
DANA-FARBER CANCER INSTITUTE, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;BRADNER, JAMES;MOELLERING, RAYMOND;VERDINE, GREGORY L.
发明人
BRADNER, JAMES;MOELLERING, RAYMOND;VERDINE, GREGORY L.