ANTISENSE GUANIDINIUM PEPTIDE NUCLEIC ACID (GPNA) OLIGONUCLEOTIDES AS ANTITUMOR AGENTS
摘要
A class of antisense agents having a distributed guanidinium peptide nucleic acids (GPNA) backbone which has excellent uptake into mammalian cells, can bind to the target DNA or RNA in a highly sequence specific manner and can resist nucleases and proteases both outside and inside the cell(s) of interest. In one embodiment, either systemic or intratumoral administration of antisense Epidermal Growth Factor Receptor ("EGFR") GPNA oligonucleotides is believed to downmodulate EGFR levels, thus in turn to reduce head and neck squamous cell carcinoma tumor growth, which has been confirmed to date both in vitro and in vivo.
申请公布号
WO2008061091(A2)
申请公布日期
2008.05.22
申请号
WO2007US84542
申请日期
2007.11.13
申请人
GRANDIS, JENNIFER, R.;THOMAS, SUFI, M.;LY, DANITH, H.
发明人
GRANDIS, JENNIFER, R.;THOMAS, SUFI, M.;LY, DANITH, H.