| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a skin composition having a melanin production inhibitory activity, penetrating through the skin while holding the barrier function of the skin, having a potent melanin production inhibitory activity and also without having safety problems such as skin irritation, skin sensitization, etc. <P>SOLUTION: By utilizing a transcription inhibitory activity of an MITF (microphthalamia transfer factor) which is a transcription factor, and blending a substance inhibiting the expression of mRNA of enzymes such as tyrosinase, etc., becoming a key enzyme of melanin production in the skin composition, the development of the skin composition having a high melanin production inhibitory activity becomes possible, and further, by blending a cationic phospholipid for penetrating a macromolecule such as nucleic acid into the skin, it becomes possible to provide the skin composition having the melanin production inhibitory activity without having problems in safety such as the skin irritation, skin sensitization, etc. <P>COPYRIGHT: (C)2008,JPO&INPIT |
