发明名称 |
PD-L2 Molecules: Novel PD-1 Ligands and Uses Therefor |
摘要 |
The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. Diagnostic and treatment methods utilizing compositions of the invention are also provided.
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申请公布号 |
US2008118511(A1) |
申请公布日期 |
2008.05.22 |
申请号 |
US20070765838 |
申请日期 |
2007.06.20 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC.;GENETICS INSTITUTE LLC |
发明人 |
FREEMAN GORDON;CHERNOVA IRENE;CHERNOVA TATYANA;MALENKOVICH NELLY;WOOD CLIVE R. |
分类号 |
A61K39/395;A61K38/16;A61K39/00;A61K48/00;A61P3/10;A61P11/06;A61P29/00;A61P31/00;A61P35/00;A61P37/00;A61P37/06;A61P37/08;C07K14/705;C12N1/15;C12N1/19;C12N1/21;C12N5/00;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;G01N33/573;G01N33/68 |
主分类号 |
A61K39/395 |
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地址 |
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