摘要 |
<p>Methods of determining levels of unbound metabolites are disclosed. Probes derived from fatty acid binding protein muteins are described that bind preferentially to a number of unbound metabolites including oleate, stearate, linoleate, palmitate, arachidonate and unconjugated bilirubin. A profile for a patient is determined using one or more of the described probes. The profile is useful in diagnosis of disease, particularly myocardial infarction, non-alcoholic fatty liver disease (NAFLD), diabetes, stroke, sepsis and neonatal jaundice. The responses of multiple probes to a test sample are used to classify the degree of acute coronary syndrome by comparison to multi-probe profiles generated from unstable angina, non ST elevation myocardial infarction, and ST elevation myocardial infarction.</p> |
申请人 |
FFA SCIENCES, LLC;KLEINFELD, ALAN;HUBER, ANDREW, HENRY;KAMPF, JAMES, PATRICK;KWAN, THOMAS;ZHU, BAOLONG |
发明人 |
KLEINFELD, ALAN;HUBER, ANDREW, HENRY;KAMPF, JAMES, PATRICK;KWAN, THOMAS;ZHU, BAOLONG |