ARYLSULFONAMIDE COMPOUNDS

摘要

The invention relates generally to small molecules that mimic the biologi cal activity of certain peptides and proteins, to compositions containing th em and to their use. In particular, the invention relates to compounds of th e general formula (I) that mimic the biological activity of BH3-only protein s and are capable of binding to and neutralising prosurvival Bcl-2 proteins: wherein A1, A2, B1, B2, B3, X, Z, R1, R2, R3 and t are as described herein. The invention also relates to processes of preparing the benzenesulfonamide compounds that mimic portions of peptides and proteins, and to the use of s uch compounds in the regulation of cell death and the treatment and/or proph ylaxis of diseases or conditions associated with the deregulation of cell de ath.