| 摘要 |
The patent of invention of the medicament telmisartana + metformin in combined form cardiovascular diseases, resums the combination of two medicaments used against the heart diseases is the main cause of death in our country there is neat correlation between the ponderal again and the weight excess with risk of heart diseases. The weight excess predisposes to these diseases because of the abnormalities in the lipides metabolism, glucose and arterial pressure. The insulin resistance / hyperinsulinemia seems to be a risk factor independent of other associated risk factors, such as the obesity, hyperlipedemia and hypertension," either in men or in women. The insulin and the growth factors like the insulin estimulate the smooth muscle cells activity and are involvied in the atherogenese and even in the reestenose that follow the coronary repair by the angioplasty. Other effects of insulin are related to mechanisms that contribute for the development either from the hypertension or from the dyslipidemia.
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