| 摘要 |
PROBLEM TO BE SOLVED: To provide a simple production method of optically active 2-[(N-benzylprolyl)amino]-5-chlorobenzophenone (3) or a salt thereof at a high purity and in a high yield. SOLUTION: The present invention relates to a production method of optically active 2-[(N-benzylprolyl)amino]-5-chlorobenzophenone (3) or a salt thereof, which includes reacting optically active N-benzylproline (1) with 2-amino-5-chlorobenzophenone (2) in acetonitrile and in the presence of an amide compound and thionyl chloride. In the formula, * shows an asymmetric carbon atom and the configuration of the asymmetric carbon atom is S or R. COPYRIGHT: (C)2008,JPO&INPIT
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