C-9 ALKENYLIDINE BRIDGED MACROLIDES

摘要

The present invention discloses compounds of formula (I), (II) or pharmaceutically acceptable salts, esters, or prodrugs thereof; Formula (I), Formula (II); which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.