发明名称 NOVEL COMPOUNDS WITH AFFINITY FOR AMYLOID
摘要 [PROBLEMS] To obtain a compound which is effective as an image diagnosis probe targeting amyloid and a diagnostic for Alzheimer's disease comprising this compound. [MEANS FOR SOLVING PROBLEMS] A compound represented by the fo llowing formula (1) or its salt: wherein A1, A2, A3 and A4 independently rep resent each carbon or nitrogen; R1 represents hydrogen or a group selected f rom the group consisting of a hydroxyl group, a carboxyl group, a sulfate gr oup, an amino group, a nitro group, a cyano group, a non-radioactive halogen substitute, a C1-4 alkyl substituent and a C1-4 alkoxy substituent; and R2 represents a radioactive halogen substituent, provided that at least one of A1, A2, A3 and A4 is carbon and R1 attaches to A1, A2, A3 or A4 that is carb on; and a diagnostic for Alzheimer's disease comprising the compound represe nted by the above formula or its salt.
申请公布号 CA2669522(A1) 申请公布日期 2008.05.22
申请号 CA20072669522 申请日期 2007.10.30
申请人 NIHON MEDI-PHYSICS CO., LTD. 发明人 TAKASAKI, SHINYA;OKUMURA, YUKI;TANIFUJI, SHIGEYUKI;NAKAMURA, DAISAKU
分类号 C07D471/04;A61K51/00 主分类号 C07D471/04
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