Sulfonamide Derivative Selectively Inhibiting Mmp-13

摘要

It is considered that MMP-13 inhibitors contribute to the treatment or prevention against the diseases caused by or related to activity of MMP-13, especially osteoarthritis (OA). Therefore, the development of MMP-13 inhibitors has been desired. A compound represented by the general formula (I): wherein Z is 1,4-phenylene and the like; R¹ is hydroxy and the like; R² is hydrogen atom, optionally substituted lower alkyl, and the like; R¹² is hydrogen atom; or R² and R¹² taken together with the adjacent carbon atom may form a ring; R³ is hydrogen atom, optionally substituted lower alkyl, and the like; R⁴ is halogen, lower alkyl, and the like; m is 0, 1, or 2; X is a bond, -C≡C-, and the like; Y is optionally substituted phenyl, optionally substituted naphthyl, and the like, its optically active substance, their pharmaceutically acceptable salt, or a solvate thereof.