发明名称 |
TRAIL RECEPTOR 2 POLYPEPTIDES AND ANTIBODIES |
摘要 |
<p>Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand ("TRAIL") Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.</p> |
申请公布号 |
EP1922337(A2) |
申请公布日期 |
2008.05.21 |
申请号 |
EP20060802591 |
申请日期 |
2006.08.28 |
申请人 |
AMGEN INC. |
发明人 |
GLINIAK, BRIAN;YANG, XIAO-DONG;WONG-MADDEN, SHARON;FOLTZ, IAN;FENG, XIAO;FITCH, ALISON;FOSTER, STEPHEN;KETCHEM, RANDALL, R. |
分类号 |
C07K16/28;A61K39/00;C12N15/13 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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