发明名称 USE OF LIPID CONJUGATES IN CYSTIC FIBROSIS AND APPLICATIONS THEREOF
摘要 This invention provides for the use of compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond in treating a subject suffering from cystic fibrosis, reducing or delaying the mortality of a subject suffering from cystic fibrosis or ameliorating symptoms associated with cystic fibrosis.
申请公布号 EP1922076(A2) 申请公布日期 2008.05.21
申请号 EP20060800600 申请日期 2006.08.01
申请人 MORRIA BIOPHARMACEUTICALS;YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM;THE TRUSTEES OF COLUMBIA UNIVERSITY 发明人 YEDGAR, SAUL;PRINCE, ALICE;YUVAL, COHEN
分类号 A61K47/48;A61K31/726;A61P11/00 主分类号 A61K47/48
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