发明名称 |
BRAIN/NEURONAL CELL-PROTECTING AGENT, AND THERAPEUTIC AGENT FOR SLEEP DISORDER |
摘要 |
A compound represented by the formula (I) or a salt thereof; and an agent for protecting a brain/neuronal cell or a therapeutic agent for sleep disorder comprising the compound or salt: wherein Z represents an oxygen or sulfur; R 1 represents an aryl or heterocyclic group which may be substituted, provided that R 1 is not a 3-ethyl-6-methoxy-2-methyl-5-naphthalen-1-yl group; R 1a represents a hydrogen atom, a hydrocarbon group which may be substituted, a hydroxyl group or the like; R 2 represents a piperidin-1,4-diyl or piperazin-1,4-diyl which may be substituted; R 3 represents a bivalent group which is formed by removing two hydrogen atoms from a benzene ring or 6-membered aromatic heterocyclic ring which may have a substituent, provided that R 3 is not a pyridazin-3,6-diyl; and R 4 represents a group which is formed by removing one hydrogen atom from a benzene ring or 5- to 6-membered heterocyclic ring which may be substituted, provided that the substituent on the heterocyclic ring is not a phenylethyl group which may be substituted when Z is sulfur.
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申请公布号 |
EP1923388(A1) |
申请公布日期 |
2008.05.21 |
申请号 |
EP20060796374 |
申请日期 |
2006.08.11 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
MATSUMOTO, TAKAHIRO;KORI, MASAKUNI;KOUNO, MITSUNORI |
分类号 |
C07D213/75;A61K31/381;A61K31/44;A61K31/4406;A61K31/496;A61K31/501;A61P1/04;A61P1/08;A61P1/12;A61P3/04;A61P3/06;A61P3/10;A61P7/02;A61P9/10;A61P11/06;A61P13/02;A61P13/10;A61P15/16;A61P15/18;A61P17/02 |
主分类号 |
C07D213/75 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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