| 发明名称 |
РЕГИОСПЕЦИФИЧЕСКИЙ СИНТЕЗ ПРОИЗВОДНЫХ 42-ЭФИРА РАПАМИЦИНА |
| 摘要 |
A method for the regiospecific synthesis of rapamycin 42-ester derivatives is described. The method involves lipase-catalyzed acetylation of 42-hydroxy of rapamycin with an acyl donor such as a vinyl ester, an isopropenyl ester or an anhydride in a suitable organic solvent. |
| 申请公布号 |
RU2006134014(A) |
申请公布日期 |
2008.05.20 |
| 申请号 |
RU20060134014 |
申请日期 |
2005.04.12 |
| 申请人 |
ВАЙЕТ (US) |
发明人 |
ГУ Джианксин (US);КАЙ Пинг (US);РУППЕН Марк Е. (US) |
| 分类号 |
C07D498/18;C07D491/14;C12P17/10;C12P17/18 |
主分类号 |
C07D498/18 |
| 代理机构 |
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