发明名称 Methods and compositions for nerve regeneration
摘要 Methods and compositions for modulating growth of a neuron with a Wnt, a Wnt-like substance, and/or a chemical compound affecting a Wnt signaling pathway are disclosed. Also disclosed are methods for identifying a substance that modulates growth of a neuron by obtaining a candidate substance and contacting the candidate substance with the neuron are disclosed and methods for modulating growth of a neuron in a subject using a Wnt, a Wnt-like substance, and/or a chemical compound affecting a Wnt signaling pathway. The Wnt, Wnt-like substance, and/or chemical compounds affecting a Wnt signaling pathway can be delivered to the subject using gene therapy techniques. Also disclosed are pharmaceutical compositions for modulating growth of a neuron in a mammal that include a Wnt or a Wnt-like substance. Methods and compositions for inhibiting growth of a neuron are also disclosed.
申请公布号 US7374760(B2) 申请公布日期 2008.05.20
申请号 US20040847972 申请日期 2004.05.17
申请人 THE UNIVERSITY OF CHICAGO 发明人 ZOU YIMIN
分类号 A61K39/00;A61K31/00;A61K38/17;A61K38/18;A61K39/395;A61P25/00;A61P25/28;C12N5/00;C12N5/06;C12N5/08;G01N33/68 主分类号 A61K39/00
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