ANTISENSE OLIGONUCLEOTIDE CONSTRUCTS BASED ON .BETA.-ARABINOFURANOSE AND ITS ANALOGUES

摘要

The present invention relates to modified oligonucleotide therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention relates to the selective inhibition of protein biosynthesis via antisense strategy using oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues. More particularly this invention relates to the use of antisense oligonucleotides having arabinose sugars to hybridiz e to complementary RNA such as cellular messenger RNA, viral RNA, etc.