摘要 |
Compounds of formula (I): wherein R<SUP>1 </SUP>represents optionally substituted C<SUB>4-12 </SUB>alkyl, optionally substituted C<SUB>2-6</SUB>alkylaryl, or optionally substituted 5- or 6-membered aryl or heteroaryl; Z represents a bond, CH<SUB>2</SUB>, O, S, SO, SO<SUB>2</SUB>, NR<SUP>4</SUP>, OCR<SUP>4</SUP>R<SUP>5</SUP>, CR<SUP>4</SUP>R<SUP>5</SUP>O, or Z, R<SUP>1 </SUP>and Q together form an optionally substituted fused tricyclic group; Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents COR<SUP>3 </SUP>or N(OR<SUP>8</SUP>)COR<SUP>9</SUP>; R<SUP>2 </SUP>represents SO<SUB>2</SUB>R<SUP>10 </SUP>or SO<SUB>2</SUB>NR<SUP>10</SUP>R<SUP>11</SUP>; R<SUP>3 </SUP>represents OR<SUP>6</SUP>, NR<SUP>6</SUP>R<SUP>7 </SUP>or NR<SUP>6</SUP>OH; R<SUP>4 </SUP>and R<SUP>5 </SUP>each independently represents H, C<SUB>1-6 </SUB>alkyl or C<SUB>1-4 </SUB>alkylaryl; R<SUP>6 </SUP>and R<SUP>7 </SUP>each independently represents H, C<SUB>1-6 </SUB>alkyl, or C<SUB>1-6 </SUB>alkyl substituted with one or more heteroaryl groups, or R<SUP>6 </SUP>and R<SUP>7 </SUP>together with the nitrogen atom to which they are attached form a 5- or 6-membered ring which may optionally include 1 or more further heteroatoms selected from O, S and N; R<SUP>8 </SUP>and R<SUP>9 </SUP>each independently represents H or C<SUB>1-6 </SUB>alkyl; R<SUP>10 </SUP>and R<SUP>11 </SUP>each independently represents H or C<SUB>1-6 </SUB>alkyl; and and physiologically functional derivatives thereof, with the exception of N-(ethoxycarbonyl)-N-[4-(1H-tetrazol-1-yl)phenyl]glycine, processes for their preparation, pharmaceutical formulations containing them and their use as inhibitors of matrix metalloproteinase enzymes (MMPs) are described.
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