Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof

摘要

The present invention provides pyrazole derivatives represented by the general formula: wherein R¹ represents H, an optionally substituted C_1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C_1-6 alkyl group etc.; R² represents H, a halogen atom, OH, an optionally substituted C_1-6 alkyl group etc.; X represents a single bond, O or S; Y represents a single bond, a C_1-6 alkylene group etc.; Z represents CO or SO₂; R⁴ and R⁵ represent H, an optionally substituted C_1-6 alkyl group etc.; and R³, R⁶ and R⁷ represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.