| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention is related to methods and compositions for treatment and/or prevention of autoimmune and/or inflammatory disease, specifically, invention presents methods of treatment to weaken expansion and functioning of autoreactive T-cells and/or NK-cells by modulation of NKG2D. Application of agent is proposed, which reduces ligand-induced activation of NKG2D white blood cells, which express NKG2D, to prepare medicinal agent for treatment or prevention of syndrome, which is associated with NKG2D-mediated activation in human subject, where syndrome is selected from group, which consists of autoimmune disease and rejection of transplant, and in which agent reduces number of NKG2D on the surface of white blood cells and contains antibody, which binds NKG2D, or its NKG2D-binding fragment. ^ EFFECT: suggested invention provides for treatment or prevention of syndrome, which is associated with NKG2D-mediated activation. ^ 33 cl, 8 ex, 17 dwg |
