COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE

摘要

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK 9 gene (PCSK 9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19 - 25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK 9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by PCSK 9 gene expression and the expression of the PCSK 9 gene using the pharmaceutical composition; and