| 摘要 |
The present invention generally relates to methods and compositions for generating vancomycin analogs. Specifically the invention relates to generating a vancomycin library through chemoselective ligation of a sugar moiety with a vancomycin aglycon. In particular, the present invention provides a library of vancomycin analogs, where the member of the library comprises at least one vancomycin analog selected from 2'-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 3'-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 4'-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 6'-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 2'-N-acylbiphenyl-glucosyl vancomycin neoglycoside, 3'-N-acylbiphenoyl-glucosyl vancomycin neoglycoside, 4'-N-acylbiphenoyl-glucosyl vancomycin neoglycoside and 6'-N-acylbiphenoyl-glucosyl vancomycin neoglycoside.
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