SELF-ASSEMBLING NANOPARTICLES COMPOSED OF TRANSMEMBRANE PEPTIDES AND THEIR APPLICATION FOR SPECIFIC INTRA-TUMOR DELIVERY OF ANTI-CANCER DRUGS
摘要
The invention provides a method of handling a hydrophobic agent, which method comprises (a) combining in an aqueous solution (i) a hydrophobic agent and (ii) an isolated peptide that is a structural analog of a transmembrane domain of an integral membrane protein, wherein one terminus of the peptide has one or more negatively charged residues, and (b) allowing the peptide to self-assemble into nanoparticles, wherein the nanoparticles comprise the hydrophobic agent.
申请公布号
WO2008058125(A2)
申请公布日期
2008.05.15
申请号
WO2007US83772
申请日期
2007.11.06
申请人
GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;TARASOVA, NADYA I.;TARASOV, SERGEY G.;MICHEJDA, CHRISTOPHER J.
发明人
TARASOVA, NADYA I.;TARASOV, SERGEY G.;MICHEJDA, CHRISTOPHER J.