POLYPEPTIDES WITH ENHANCED ANTI-INFLAMMATORY AND DECREASED CYTOTOXIC PROPERTIES AND RELATING METHODS
摘要
The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a a 2, 6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody.
申请公布号
WO2008057634(A2)
申请公布日期
2008.05.15
申请号
WO2007US72771
申请日期
2007.07.03
申请人
THE ROCKEFELLER UNIVERSITY;NIMMERJAHN, FALK;YOSHIKATUS, KANEKO;RAVETCH, JEFFREY, V.
发明人
NIMMERJAHN, FALK;YOSHIKATUS, KANEKO;RAVETCH, JEFFREY, V.