| 摘要 |
A method is provided for introducing a GAG binding site into a protein comprising the steps: identifying a region in a protein which is not essential for structure maintenance introducing at least one basic amino acid into said site and/or deleting at least one bulky and/or acidic amino acid in said site, whereby said GAG binding site has a GAG binding affinity of Kd<=10 muM, preferably <=1 muM, still preferred <=0.1 muM, as well as modified GAG binding proteins.
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