发明名称 |
RNAi MODULATION OF AHA AND THERAPEUTIC USES THEREOF |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an Aha gene (Aha1 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an Aha gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier, methods for treating diseases caused by Aha1 expression and the expression of an Aha gene using the pharmaceutical composition; and methods for inhibiting the expression of an Aha gene in a cell.
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申请公布号 |
US2008113931(A1) |
申请公布日期 |
2008.05.15 |
申请号 |
US20070750553 |
申请日期 |
2007.05.18 |
申请人 |
CONSTIEN RAINER;BRAMLAGE BIRGIT;TAN PAMELA;VORNLOCHER HANS-PETER;BALCH WILLIAM |
发明人 |
CONSTIEN RAINER;BRAMLAGE BIRGIT;TAN PAMELA;VORNLOCHER HANS-PETER;BALCH WILLIAM |
分类号 |
A61K31/7088;A61P43/00;C07H21/02;C12N1/00;C12N15/09;C12N15/113;C12N15/63 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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