METHOD FOR SCREENING DRUG CANDIDATES FOR INFLAMMATORY DISEASES MEDIATED BY LPS-INDUCIBLE CC CHEMOKINE RECEPTOR MECHANISM

摘要

The present invention relates to an in vitro and in vivo screening methods for identifying novel drugs for inflammatory diseases mediated by LPS-inducible CC chemokine receptor, particularly allergic airways diseases or rheumatoid arthritis. The allergic airways disease is particularly asthma. Inhibitors of CCRL2 receptor are also disclosed, as well as a method of treatment such diseases by using these inhibitors. In particular, the screening method of the invention comprises a step of putting into contact a CCRL2- expressing cell preparation with a drug candidate for CCRL2 inhibition and then evaluating the degree of CCRL2- expressing cell migration against a control.