| 摘要 |
The present invention relates to a process of the preparation of (S)-4-fl uoromethyl-dihydro-furan-2-one of the formula (I) by employing a dialkylmalo nate of the formula (V) wherein R1b is lower alkyl, and the use of this proc ess for the manufacture of DPP-IV inhibitors that are useful for the treatme nt and/or prophylaxis of diseases such as diabetes.
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