GLP-1 DERIVATIVE AND USE THEREOF

摘要

[PROBLEMS] To provide a novel GLP-1 derivative having a largely improved capability of being absorbed through a mucous membrane. [MEANS FOR SOLVING PROBLEMS] Disclosed is a peptide which has (Lys)n-Arg [wherein n represents an integer of 4 to 8, and Arg is in the form of a carboxylic acid] added to the C-terminus of a peptide comprising an amino acid sequence corresponding to GLP-1 (7-35) or GLP-1 (7-36) or an amino acid sequence having the deletion, substitution and/or addition of one or several amino acid residues in the aforementioned amino acid sequence, having at least 85% homology to the aforementioned amino acid sequence and having a GLP-1 activity. The amino acid residue at position-8 in the amino acid sequence for GLP-1 is preferably serine or glycine, and the integer "n" is preferably 5.