ALPHAVIRUS AND ALPHAVIRUS REPLICON PARTICLE FORMULATIONS ANDMETHODS

摘要

Disclosed are methods for preparing dried (preferably lyophilized) prepar ations comprising a population of alphaviruses or alphavirus replicon partic les, a sugar or polyol, a surfactant and a salt and preparations made by sai d methods, both in the dried form but also as liquids prior to drying or aft er reconstituting dried preparations. These preparations may further compris e a plasticizer and/or a bulking agent. These preparations are readily recon stituted, with little or no loss in infectivity of the viruses or replicon p articles.