| 摘要 |
Process for the preparation of 2,5-bis(2,2,2-trifluoroethoxy)-N-(2- piper idylmethyl)benzamide, its pharmaceutically acceptable salts and important in termediates thereof that involves 1,4-dihalotoluenes as starting material. T he method involves a technique for preparing the starting material 2,5-bis(2 ,2,2-trifluroethoxy)toluene in high yields by reacting 1,4- dibromotoluene w ith 2,2,2-trifluoroethanol in presence of a base and a copper-containing cat alyst.
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