| 摘要 |
A biologic ventricular assist device that also has the capability to capt ure, grow, and administer stem cells to regenerate and restore damaged myoca rdium in the heart. The device works in conjunction with a traditional ventr icular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified ce lls or other therapeutic biologic or pharmacologic agents, as well as leadin g to a stem cell collecting accessory (14) that captures circulating stem ce lls. The stem cell collecting accessory is also associated with a chamber (3 9) for culturing the captured stem cells. The cultured stem cells can be del ivered back to the heart by an electro-mechanical or ultrasound/echocardiogr aphic delivery system that runs through the external path back into the vent ricular assist device and allows for the delivery of the stem cells, or othe r therapeutic biologic or pharmacologic agents, directly into the internal c hambers of the heart. Administering the stem cells, genes, genetically modif ied cells or other therapeutic biologic or pharmacologic agents, either alon e or in combination, to the heart allows the myocardium to regenerate and re pair itself even while the heart is attached tothe ventricular assist device , ultimately allowing the heart to regenerate, recover and allow the VAD to be removed.
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