| 摘要 |
<p>Antagonists of human proprotein convertase subtilisin-kexin type 9 ("PCSK 9") are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the u se in the treatment of conditions associated with PCSK9 activity. The presen t invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making P CSK9-specific antagonists as well as methods of using the antagonists for in hibiting or antagonizing PCSK9 function are also disclosed and form importan t additional aspects of the present disclosure.</p> |
