PREDICTION OF POTENTIAL DRUG-DRUG INTERACTIONS USING GENE EXPRESSION PROFILING OF DRUG TRANSPORTERS, CYTOCHROME P450S AND NUCLEAR X RECEPTORS

摘要

The invention provides materials and methods for detecting the expression of genes encoding cytochrome p450, nuclear X receptors, phase II transferases, and solute carrier family uptake pumps. The materials include sets of primers, PCR amplicons and arrays. The methods of the invention include hybridization assays. Kits and assays for the detection of the expression of the genes are also provided by the invention. In addition, the invention provides the use of the materials and methods of the invention in drug screening assays.