发明名称 |
METHOD OF TARGETING SPECIFIC CELL POPULATIONS USING CELL-BINDING AGENT MAYTANSINOID CONJUGATES LINKED VIA A NON-CLEAVABLE LINKER, SAID CONJUGATES AND METHODS OF MAKING SAID CONJUGATES |
摘要 |
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
|
申请公布号 |
US2008114153(A1) |
申请公布日期 |
2008.05.15 |
申请号 |
US20070927217 |
申请日期 |
2007.10.29 |
申请人 |
IMMUNOGEN. INC. |
发明人 |
STEEVES RITA;LUTZ ROBERT;CHARI RAVI;XIE HONGSHENG;KOVTUN YELENA |
分类号 |
C07K14/705;C07D491/14 |
主分类号 |
C07K14/705 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|