| 发明名称 |
ALPHA(1,3) GALACTOSYLTRANSFERASE NEGATIVE SWINE |
| 摘要 |
<p>Transgenic swine in which the normal expression of alpha(1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Galalpha1-3Galbeta1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.</p> |
| 申请公布号 |
EP0755402(B1) |
申请公布日期 |
2008.05.14 |
| 申请号 |
EP19950915459 |
申请日期 |
1995.03.31 |
| 申请人 |
BIOTRANSPLANT, INC;THE GENERAL HOSPITAL CORPORATION;INSTITUTE OF CHILD HEALTH |
发明人 |
BAETSCHER, MANFRED, W.;SACHS, DAVID, H.;GUSTAFSSON, KENTH, T. |
| 分类号 |
A01K67/027;C12N15/54;A61K31/70;A61K35/12;A61K35/16;C07H21/04;C12N9/00;C12N9/10;C12N15/00;C12N15/09;C12N15/113;C12N15/19;C12N15/52;C12N15/85 |
主分类号 |
A01K67/027 |
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