发明名称 |
METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF ANEMIA |
摘要 |
<p>Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematrocrit and treat anemia. Also disclosed are new hyperglycosylated erythropoietin analogs, methods of production of the analogs, and compositions comprising the analogs.</p> |
申请公布号 |
EP1274728(B1) |
申请公布日期 |
2008.05.14 |
申请号 |
EP20010928685 |
申请日期 |
2001.04.19 |
申请人 |
AMGEN INC. |
发明人 |
EGRIE, JOAN, C.;ELLIOTT, STEVEN, G.;BROWNE, JEFFREY, K.;SITNEY, KAREN, C. |
分类号 |
C07K14/505;C12N15/09;A61K38/00;A61K38/18;A61K38/22;A61K47/10;A61K47/12;A61K47/42;A61P7/06;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N5/10;C12N15/12;C12N15/66 |
主分类号 |
C07K14/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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