Thermosensitive biodegradable copolymer

摘要

A thermo-sensitve copolymer of following formula; is disclosed; wherein R1 is hydrogen, or -C(=O)-R2; R2 is C7-30 alkyl substituted or unsubstituted with functional groups; R3 is hydrogen, or C1-6 alkyl; and x, y or z individually is an integer greater than 0. The thermo-sensitive copolymers disclosed here are easy to be implanted into a human body through injection for controlled drug release systems or as embolic agents. The subunits in the polymer are chosen among blocks of PEG (polyethylene glycol) and PLGA (poly (lactide - co -glyceride)). The biodegradability is greatly improved and the cytotoxicity of the copolymers is low.