发明名称 |
Beta-glucan-based anti-fungal vaccines |
摘要 |
Anti-glucan antibodies have been found to be protective against systemic fungal infection with C.albicans, but the protective efficacy can be inhibited by blocking antibodies. The invention provides an immunogenic composition comprising a glucan and a pharmaceutically acceptable carrier, characterised in that, when administered to a mammalian recipient, the composition elicits protective anti-glucan antibodies but does not elicit antibodies which inhibit the protective efficacy of the anti-glucan antibodies. The glucan may be presented on the surface of a protease-treated microbial cell or may be presented as a protein-glucan conjugate. Anti-glucan-antibodies show broad spectrum microbicidal activity. ²-glucans are preferred, particularly those containing one or more ²-1,6 linkages. |
申请公布号 |
EP1506009(B1) |
申请公布日期 |
2008.05.14 |
申请号 |
EP20030730424 |
申请日期 |
2003.05.15 |
申请人 |
POLONELLI, LUCIANO;CASSONE, ANTONIO |
发明人 |
POLONELLI, LUCIANO;CASSONE, ANTONIO |
分类号 |
A61K39/385;C12N15/09;A61K31/7088;A61K31/716;A61K35/76;A61K36/06;A61K38/00;A61K39/00;A61K39/05;A61K39/09;A61K39/13;A61K39/145;A61K39/155;A61K39/205;A61K39/29;A61K39/39;A61K39/395;A61K45/00;A61P31/00;A61P31/04;A61P31/06;A61P31/10;A61P33/02;A61P33/08;A61P43/00;C07K14/00;C07K16/14;C12N1/14;C12R1/725 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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