Quinoline derivatives having VEGF inhibiting activity

摘要

The invention relates to compounds of formula (I) wherein: either any one of G₁, G₂, G₃, G₄ and G₅ is nitrogen and the other four are -CH-, or G₁, G₂, G₃, G₄ and G₅ are all -CH-; Z is -O-, -NH-, -S-, -CH₂- or a direct bond; Z is linked to any one of G₁, G₂, G₃ and G₄; n is an integer from 0 to 5; m is an integer from 0 to 3; R^a represents hydrogen or fluoro; R^b, R¹ and R² are defined herein and salt thereof, process for the preparation so such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and the use of a compound of formula I in the manufacture of a medicament for the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of diseases states including cancer and rheumatoid arthritis.