发明名称 |
Non-racemic trifluoroleucine, and methods of making and using |
摘要 |
One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluoroleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbon-fluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.
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申请公布号 |
US7371867(B2) |
申请公布日期 |
2008.05.13 |
申请号 |
US20060593443 |
申请日期 |
2006.11.06 |
申请人 |
TRUSTEES OF TUFTS COLLEGE |
发明人 |
FICHERA ALFIO;BILGICER ZIHNI;KUMAR KRISHNA;XING XUECHAO |
分类号 |
C07D211/82;C07C211/00;C07C237/20;C07C237/30;C07C271/22;C07C327/30;C07C327/40;C07K5/06 |
主分类号 |
C07D211/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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