发明名称 |
Prostate-specific antigen probes for optical imaging |
摘要 |
This invention provides a novel probe, which contains a prostate peptide substrate. The probe can be used as a prostate diagnostic agent for optical imaging. An 11 amino acid peptide substrate is synthesized for specific prostate-specific antigen (PSA). This protected graft copolymer (PGC) consists of a poly-L-lysine (PL) backbone and methoxypoly(ethylene glycol) (MPEG). Two terminals of peptide substrate are bound to poly-L-lysine and Cy5.5 fluorochrome. This probe will be used as a NIR (near-infrared fluorescence) probe for optical imaging.
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申请公布号 |
US7371728(B2) |
申请公布日期 |
2008.05.13 |
申请号 |
US20060325074 |
申请日期 |
2006.01.04 |
申请人 |
KAOHSIUNG MEDICAL UNIVERSITY |
发明人 |
WANG YUN-MING;CHAO WEI-HSAN;LIU GIN-CHUNG;HSU JUI-SHENG |
分类号 |
A61K38/08;A61K38/00;A61K38/02;C07K1/00;C07K2/00;C07K7/04 |
主分类号 |
A61K38/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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