发明名称 |
Bis-transition-metal-chelate probes |
摘要 |
A molecule for labeling a target material is provided including two transition-metal chelates and a detectable group. The molecule has the general structural formula (I): wherein: (a) Y and Y' are each a transition metal, (b) R<SUP>1 </SUP>and R<SUP>1' </SUP>are each independently CH(COO<SUP>-</SUP>), CH(COOH), or absent; (c) R<SUP>2 </SUP>and R<SUP>2' </SUP>are linkers each having a length of from about 3.0 to about 20 Å; and (d) X is a detectable group. The linkers may be linear or branched, may contain aromatic moieties, and may optionally be further substituted. Methods of using the molecules of the invention as probes in detecting and analyzing target materials as well as kits including the molecule of the invention are also provided.
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申请公布号 |
US7371745(B2) |
申请公布日期 |
2008.05.13 |
申请号 |
US20040946786 |
申请日期 |
2004.09.21 |
申请人 |
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY |
发明人 |
EBRIGHT RICHARD H.;EBRIGHT YON W. |
分类号 |
A61K31/352;A61K31/538;C07D209/14;C07D265/28;C07D407/06;C12Q1/68;G01N33/533 |
主分类号 |
A61K31/352 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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