| 摘要 |
The present invention relates to compounds of formula I: (I) or a pharmaceutically acceptable acid addition salt thereof, where; X is C(R= or N=; Ris C-Calkyl, substituted C-Calkyl,С-Сcycloalkyl, substituted C-Ccycloalkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; Ris hydrogen,С-Сn-alkyl, C-Ccycloalkyl -С-Сalkyl, or a group of formula II (II) provided that when Ris C-Calkyl or substituted C-Calkyl, Ris hydrogen or methyl; R, R, and, when X is C(R)=, R, are each independently hydrogen, fluoro, or methyl, provided that no more than one of R, R, and Rmay be other than hydrogen; Ris hydrogen orС-Сalkyl; Ris hydrogen,С-Сalkyl, or C-Ccycloalkylcarbonyl, provided that when Ris other than hydrogen, Ris hydrogen; Ris hydrogen orС-Сalkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HTreceptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal.I,II. |
