| 摘要 |
FIELD: CHEMISTRY. ^ SUBSTANCE: invention relates to novel method for preparation of compounds of formula IX or IX, which implies reaction of compound of formula Va, in solvent, with compound of formula VII or formula VIIa, in the presence of palladium catalyst and phospho ligand, in the presence of amine base, resulting in compound of formula VIII or VIIIa. The method also implies reaction of compound of formula VIII or VIIIa, in solvent, with cyclopropylamine, not necessarily in the presence of catalyst. Also, invention relates to method for purification of compound of formula IX or IXa. ^ Va - R1 may be either 1-8alkyl, aryl or heteroaryl, not necessarily aryl- and/or 1-8alkyl-substituted; and ^ . ^ EFFECT: method for preparation of biologically useful compounds is described. ^ 17 cl, 3 tbl, 77 ex |
