| 摘要 |
Use of a compound of formula (I): wherein: R<SUP>1 </SUP>is phenyl optionally substituted by halogen, cyano, C<SUB>1-4 </SUB>alkyl or C<SUB>1-4 </SUB>haloalkyl; R<SUP>2 </SUP>is hydrogen, C<SUB>1-6 </SUB>alkyl or C<SUB>3-6 </SUB>cycloalkyl; and R<SUP>3 </SUP>is a group having an NH or OH that has a calculated or measured pKa of 1.0 to 8.0; or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment of osteoarthritis or osteoarthrosis. The invention also concerns the benzenesulfonate salt of N-{3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-2,3-dihydro-2-oxo-4-(trifluoromethyl)-5-thiazolecarboxamide, a process for making it, and its use in therapy (for example in treating CCR3 mediated disease states).
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