| 摘要 |
A cyclovitamin D derivative produced from 25-hydroxyvitamin D is reacted with osmium tetraoxide or a permanganic acid salt to produce a 10,19-diolcyc lovitamin D derivative. The 10,19-diolcyclovitamin D derivative is reacted w ith a perhalogenic acid salt or lead tetraacetate to produce a 10-oxocyclovi tamin D derivative. A 1-hydroxycyclovitamin D derivative is produced from th e 10-oxocyclovitamin D derivative via a cyclovitamin D derivative and a 1,10 -olefincyclovitamin D derivative. The 1-hydroxycyclovitamin D derivative is subjected to solvolysis, thereby producing a 1-hydroxy-19-norvitamin D deriv ative. Thus, provided are: a novel process for producing a 1-hydroxy-19-norv itamin D derivative which can be used as an intermediate for the synthesis o f a 1-hydroxy-19-norvitamin D derivative which is useful as a pharmaceutical agent; and an intermediate for the production.
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