发明名称 |
Compounds and Their Use for Specific and Simultaneous Inhibition of Genes Involved In Diseases and Related Drugs |
摘要 |
The invention relate to the use of a compound of formula A-B-C Wherein A is a DNA sequence-specific ligand capable of simultaneously and specifically recognizing a sequence common to genes of pathological interest; B is a linker arm, said linker arm being bound to the 3' end of A; C is a topoisomerase I posion; for the preparation of a drug for the treatment of a disease brought about by the expression of a gene and said gene is inhibited by the stabilized topoisomerase I-mediated DNA cleavage. Application, particularly, for the treatment of infective microorganism or virus, dismetabolic disease and autoimmune disease.
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申请公布号 |
US2008108581(A1) |
申请公布日期 |
2008.05.08 |
申请号 |
US20040549129 |
申请日期 |
2004.03.18 |
申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (I.N.S.E.R.M.);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.);MUSEUM NATIONAL D'HISTOIRE NATURELLE |
发明人 |
ARIMONDO PAOLA BARBARA;BOUTORINE ALEXANDRE;SUN JIAN-SHENG;BAILLY CHRISTIAN;HELENE CLAUDE;GARESTIER THERESE |
分类号 |
A61K48/00;A61K31/4162;A61K38/00;A61P35/00;A61P43/00;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
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主权项 |
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地址 |
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